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. 2021 Jan 27;12:626. doi: 10.1038/s41467-020-20883-w

Fig. 7. LFY DNA contact helix and motif preference.

Fig. 7

a Structure of the known pioneer transcription factor FoxA (PDB:5X07 [https://www.rcsb.org/structure/5X07]), and LFY monomer (top right) or dimer (bottom) (PDB: 2VY1) bound to DNA. Red: All base contacting residues, including the DNA anchoring helix. Arrows delineate the DNA region contacted. b Position weight matrices of top motifs identified by de novo motif analysis (HOMER) in naked DNA (LFY motif (free); p value =1E-43) or in nucleosomes (LFY motif (nucl.); p value = 1E-48). The nucleosomal LFY motif diverges more from the known CCANTGG56, 57 core consensus motif. Asterisk: Center of the palindrome. See also Supplementary Fig. 6.