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. 2021 Jan 27;12:626. doi: 10.1038/s41467-020-20883-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — LFY binds to a nucleosome occupied target site and locally opens chromatin by displacing H1 linker histones (light green ellipse) and by recruiting SWI/SNF chromatin remodelers (SWI hexagon). This leads to low initial activation of gene expression (small arrow and RNA polymerase II (Pol II)). The local chromatin unlocking enables additional transcription factors to bind the locus, these include LMI2, SPL9/DELLA (SPD) and the florigen activation complex (FAC). See text for details. This in turn leads to recruitment of other chromatin regulators (CHR pentagon), increased gene activation (large arrow and Pol II), accumulation of the floral fate commitment factor AP1 and cell fate reprogramming. pTF pioneer transcription factor. TF non-pioneer transcription factor.