Fig. 6. Anti-PstS1 mAbs inhibit Mtb in Balb/c mice.

Activity of anti-PstS1 mAbs: p4-36 (magenta bars), p4-163 (dark-blue bars), as well as the negative control mAb mGO53 (gray bars) at indicated concentrations in Balb/c mice. Mice were injected once intraperitoneally with mAbs at indicated amounts 5 hours prior to aerosol infection with pathogenic Mtb. Mice were euthanized after 2 weeks, and lung bacterial burden measured. Error bars are represented as mean±SD. In each treatment n = 6 mice. Significance was determined using a two-tailed unpaired t test. ns no significance. The results are representative of three independent experiments.