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. 2017 Aug 7;25(7):1189–1197. doi: 10.3727/096504017X14865126670075

Figure 4.

Figure 4

Upregulation of miR-214 reversed LINC0086-mediated inhibitory effects in vitro and in vivo. (A) CCK-8 was used for measuring cell proliferation. miR-214 overexpression reversed LINC0086-mediated inhibition of cell proliferation in C666-1 and HK-1 cells. (B) Flow cytometry was used for measuring cell apoptosis. miR-214 overexpression reversed LINC0086-mediated promotion of cell apoptosis in C666-1 and HK-1 cells. (C) The C666-1 cells transfected with LINC0086 or together with miR-214 were injected into nude mice. The cells transfected with empty plasmid were used as negative control. Right: Tumors obtained from mice on day 28 after injection. Left: Tumor volumes were calculated every week. (D) Representative image of IHC staining of Ki-67 in xenografted tumor section. Magnification: 200×. *p < 0.05, **p < 0.01.