Table 8.

Pharmacotherapy for children, adolescents, and adults under non-intensive conditions (e.g., outpatient setting)

Substance	Administration	<7.5 kg BW	7.5–25 (–30)d kg BW	30–60 kg BW	>60 kg BW
Adrenaline	Intramuscular	50–600 μg
Adrenaline	Auto-injector i.m.	Not approved	150 µg	300 µg	1–2 × 300 µg or 500 µg
Adrenaline	Inhalation nebulizer	2–5 mlb
Adrenaline	Intravenousa	Titrating bolus doses 1 μg/kg BW
Dimetindene	Intravenous	1 mlc	1 ml/10 kg BWc (max. 4 ml)	1 Amp = 4 mlc	1–2 Amp = 4–8 mlc (1 ml/10 kg BW)
Prednisolone	Intravenous	50 mg	100 mg	250 mg	500–1000 mg
Salbutamol Terbutaline	Inhaled	2 Puffs via spacer	2 Puffs via spacer	2–4 Puffs via spacer	2–4 Puffs via spacer
Volume	Bolus (NaCl 0.9%)	20 ml/kg BW	20 ml/kg BW	10–20 ml/kg BW	10–20 ml/kg BW
Oxygen	Inhaled	2–10 l/min	5–12 l/min	5–12 l/min	5–12 l/min

AMP ampoule, BW body weight

^aFor intravenous administration, a 1-mg/ml adrenaline solution is diluted in 100 ml NaCl 0.9% (final concentration, 10 mg/ml)

^bFor inhalation, the original concentration of the commercial solution is used (1 mg/ml)

^cAn original concentration of 1 mg/ml (1 ml contains 1 mg dimetindene maleate)

^dVarious weight-dependent approvals for different auto-injectors