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Regulatory effect of PI3K/Akt signaling pathways on TRAF4-induced cell mobility. (A) Constitutive activation of Akt1 recovered cell migration and invasion impaired by TRAF4 downregulation (p < 0.05). (B) PI3K/Akt inhibitor LY294002 hampered the TRAF4-induced cell migration and invasion (p < 0.05). Data are presented as the mean ± SD; n = 6. *p < 0.05. All experiments were repeated independently three times; significant difference between groups: *p < 0.05.
