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. 2017 Nov 2;25(9):1529–1541. doi: 10.3727/096504017X14888987683152

Figure 7.

Figure 7

UCA1 siRNA suppresses tumor growth and metastasis in vivo. Xenograft mouse model was created by subcutaneous injection of SW1990 cells pretreated with UCA1 scramble or UCA1 siRNA to SPF nude mice. (A) Representative tumors from two groups of mice are shown (n = 5). (B) Tumor growth trend in UCA1 scramble or UCA1 siRNA group mice is shown (*p < 0.05, **p < 0.01 vs. UCA1 scramble group). (C, D) The expression of UCA1 and miR-135a in UCA1 scramble and UCA1 siRNA group mice was detected through qRT-PCR and Western blotting (***p < 0.001 vs. UCA1 scramble). (E) Expression of migration markers MMP-2 and MMP-9 in formalin-fixed, paraffin-embedded tumors from UCA1 scramble or UCA1 siRNA group mice was detected through immunohistochemistry (IHC) analysis.