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Downregulation of FOXR2 inhibits CRC cell proliferation and invasion in vitro. Western blot assay showed decreased FOXR2 protein expression after siRNA-mediated downregulation in SW480 (A) and HT29 (B) cells. Downregulation of FOXR2 remarkably inhibited the proliferation rate of SW480 (C) and HT29 (D) cells as measured by the MTT assay. Downregulation of FOXR2 significantly inhibited the invasive capability of SW480 (E) and HT29 (F) cells as measured by the Transwell assay. *p < 0.05.
