Figure 3.

(A) Cell death responsiveness (propidium iodide positivity) of melanoma cell lines after single and combination treatment with birinapant and dacarbazine (48 h, 5 × 5 combination matrices). Bars represent mean values from three independent experiments, each run with triplicate samples. Error bars (typically <5% SEM) were omitted for clarity. (B) Effect of birinapant on melanoma cell proliferation. GAPDH amounts were measured by ELISA-based Luminex technology and shown as median fluorescence intensity (mfi).