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Ectopic expression of PRSS8 inhibited the activation of the JAK/STAT3 signaling pathway in NSCLC cells. A549 cells were transfected with PRSS8 or mock for 24 h. (A) Western blot assays were performed to detect the expression of p-JAK1, JAK1, p-JAK2, JAK2, p-STAT3, and STAT3. (B) Graphic presentation of the ratio of p-JAK1/JAK1, p-JAK2/JAK2, and p-STAT3/STAT3. Experiments were performed in triplicate. *p < 0.05 versus mock group.
