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. 2021 Jan 14;8:624678. doi: 10.3389/fchem.2020.624678

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Copyright © 2021 Garcia, Oliveira, Jesus, Souza, Sodero, Vermelho, Leal, Souza, Miranda, Pinheiro and Rodrigues.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of the chalcone derivatives that showed LiARG inhibition >50%. LC14: 1-(4-bromophenyl)-3-(3,4-dimethoxyphenyl)- 2-Propen-1-one; LC32: 1-(2-Chlorophenyl)- 3-(4-fluorophenyl)-2-Propen-1-one; LC34: 1-(2-Chlorophenyl)- -(4-Methoxyphenyl)-2-Propen-1-one; LC37: 3-hydroxy-2-[-hydroxy(2-Chlorophenyl)methyl]-3-(2-Chlorophenyl)-1-phenyl-1-Propanone; LC39: 1-(4-Bromophenyl)- 3-(4-Nitrophenyl)-2-Propen-1-one; LC41: 1-(4-Methoxyphenyl)- 3-(4-Nitrophenyl)-2-Propen-1-one.