Table 2.
LiARG inhibition, anti-L. infantum activity and cytotoxicity of chalcone derivatives.
| Chalcone |
ARGLi inhibition (%) (100 μM) |
RAW 264.7 | Promastigotes | Amastigotes | Selectivity Index | |
|---|---|---|---|---|---|---|
|
CC50 ± SE (μM) |
IC50 ± SE (μM) |
IC50 ± SE (μM) |
PRO | AMA | ||
| LC14 | 65.4 ± 2.8 | 75.1 ± 8.9 | 283.4 ± 14.2 | n.d. | <1 | n.d |
| LC32 | 69.5 ± 7.9 | 479.1 ± 19.5 | 74.1 ± 10.9 | 111.5 ± 19.8 | 6.5 | 4.3 |
| LC34 | 59.9 ± 9.2 | 3,010.9 ± 88.0 | 747.2 ± 22.3 | 65.4 ± 10.9 | 4.0 | 46.0 |
| LC37 | 58.9 ± 9.2 | >4,000 | >1,500 | n.d. | n.d. | n.d |
| LC39 | 71.9 ± 11.6 | 4531.0 ± 212.0 | 398.0 ± 44.2 | 42.3 ± 17.1 | 11.4 | 107.1 |
| LC41 | 72.3 ± 0.3 | 1,146.8 ± 58.8 | 319.1 ± 14.3 | 43.7 ± 13.7 | 3.6 | 26.2 |
| Fungizone® | n.d | 11.9 ± 0.2 | 0.024 ± 0.0007 | 0.138 ± 0.01 | 503.2 | 86.9 |