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. 2017 Mar 13;25(3):427–435. doi: 10.3727/096504016X14747300207374

Figure 6.

Figure 6

SOX7 is a direct and functional target of miR-935 in HCC. (A) Transfection of miR-935 mimics in liver cancer cells significantly inhibited SOX7 expression levels, as assessed by Western blot analysis. (B) Transfection of miR-935 mimics in liver cancer cells significantly promoted cyclin D1 and c-Myc mRNA expression levels, as assessed by RT-PCR analysis. (C) The correlation between the relative miR-935 expression and the relative SOX7 expression in liver cancer specimens was analyzed. Cell proliferation was detected by the CCK-8 assay at 0, 24, 48, 72, and 96 h after transfection with NC or SOX7 siRNA in HepG2 (D) and BEL7402 (E) cells. Transwell chambers were used to analyze the migration and invasion capabilities after transfection with NC or SOX7 siRNA in HepG2 (F) and BEL7402 (G) cells.