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Knockdown of TMEM45B inhibited the activation of the Wnt/β-catenin pathway in osteosarcoma cells. (A) U2OS cells were transfected with shTMEM45B or shNC for 48 h, respectively. The expression of β-catenin, cyclin D1c, and c-Myc proteins was then analyzed by Western blotting. (B) Expression of β-catenin, cyclin D1, and c-Myc proteins was analyzed using Gel-Pro Analyzer version 4.0 software and normalized to GAPDH. *p < 0.05, compared with the shNC group.
