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. 2017 Apr 14;25(4):551–558. doi: 10.3727/096504016X14758370595285

Figure 4.

Figure 4

Overexpression of TRIM16 inhibits the activation of Sonic hedgehog signaling cascade in ovarian cancer cells. SKOV3 cells were transfected with TRIM16 or empty vector for 24 h. (A) Western blot assays were performed to detect the expression of Shh, Smo, Ptc, and Gli-1 in SKOV3 cells. (B) The relative protein expression levels of Shh, Smo, Ptc, and Gli-1 were quantified using Image-Pro Plus 6.0 software and normalized to GAPDH. Results are means ± SD from three independent experiments performed in duplicate. *p < 0.05 compared with empty vector group.