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. 2017 Nov 2;25(9):1555–1566. doi: 10.3727/096504017X14897158009178

Figure 6.

Figure 6

Knockdown of E2F3a in glioma cells reduced tumor growth in vivo. U373 cells infected with shRNA control (shNC) or E2F3a-shRNA were subcutaneously injected into athymic nude mice. Tumor growth was shown 45 days after injection. (A) Time course analysis of tumor growth after injection. (B) Tumor growth was significantly reduced in E2F3a knockdown tumors. (C–F) The expression of E2F3a, PCNA, and Ki-67 in xenografts from the nude mice was determined by Western blot and immunohistochemical analysis (G–I). **p < 0.01, ***p < 0.001 compared with corresponding control cells.