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. 2021 Jan 14;8:605979. doi: 10.3389/fcell.2020.605979

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Copyright © 2021 Bai, Jia, Kang, Fu, Zhou, Zhong, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profile of global metabolomics and lipidomics data. (A–D) Principal component analysis (PCA) of metabolomics (A,B) and lipidomics (C,D) profile of wild-type (WT) and gcgr^−/− were indicated by different color circles. PCA scores were plotted in both positive mode (A,C) and negative mode (B,D). (E,F) Volcano plots of all identified metabolites from metabolomics (E) and lipidomics (F) analysis. The x-axis indicates Log2 (fold change) while the y-axis indicates -Log10 (P-value). Every single metabolite is represented as a dot. Different colors were used to represent down-regulated (blue), up-regulated (red), or non-significant (gray) metabolites. (G) Pie charts showing different classes of total different, elevated, and decreased metabolites. Different colors indicate different classes.