Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 14;8:605979. doi: 10.3389/fcell.2020.605979

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Bai, Jia, Kang, Fu, Zhou, Zhong, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

GCGR knockout influenced the tryptophan metabolism and locomotor activity in zebrafish. (A) Disturbed tryptophan metabolism. Dots represent metabolites, and blocks represent transcripts-encode enzymes. Red: up-regulated blue: down-regulated; gray: unvaried substrates. (B) Experimental validation of the melatonin level. (C) Locomotor activities were monitored in gcgr^−/− mutants and WT zebrafish larvae under LD condition. (D,E) gcgr^−/− mutants showed higher average moving distances at day (D) and night (E) than WT zebrafish larvae. Student t-test was conducted. *P < 0.05, **P < 0.01, ***P < 0.001.