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. 2021 Jan 27;12(1):131. doi: 10.1038/s41419-021-03401-8

Fig. 4. Cdk5rap3∆/∆IEC mice are susceptible to experimentally induced colitis.

Fig. 4

Mice of each genotype were treated with 2.5% DSS in drinking water for 5 consecutive days and monitored for weight loss and clinical symptoms such as diarrhea and blood in stools. a Weight loss of DSS-treated mice **p < 0.01 (n = 5 mice per genotype). b Clinical scores of diarrhea of DSS-treated mice. Diarrhea (0 = no diarrhea, 1 = soft stool, 2 = very soft stool, 3 = liquid stool, 4 = severe diarrhea). *p < 0.05 (n = 5 mice per genotype). c Colon length. ***p < 0.001 (n = 5 mice per genotype). d H&E staining of colonic sections of wild-type and Cdk5rap3 deficient mice after DSS treatment. e Elevated expression of inflammatory cytokines in Ufbp1 deficient mice after DSS treatment. Total colonic RNA was subjected to quantitative RT-PCR analysis. ****p < 0.0001 (n = 5 mice per genotype).