Table 3.
GO analysis of DEGs.
| GO-ID | Term | Count | p value |
|---|---|---|---|
| Biological process (BP) | |||
| GO:0006334 | Nucleosome assembly | 12 | 1.80E−05 |
| GO:0006351 | Transcription, DNA-templated | 61 | 1.50E−04 |
| GO:0043484 | Regulation of RNA splicing | 6 | 2.00E−04 |
| GO:0008380 | RNA splicing | 12 | 2.00E−04 |
| GO:0071456 | Cellular response to hypoxia | 8 | 0.002 |
| GO:0048536 | Spleen development | 5 | 0.005 |
| GO:0098609 | Cell–cell adhesion | 13 | 0.006 |
| GO:0006397 | Mrna processing | 10 | 0.008 |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | 24 | 0.012 |
| GO:0051028 | mRNA transport | 5 | 0.012 |
| GO:0045814 | Negative regulation of gene expression, epigenetic | 5 | 0.015 |
| GO:0045931 | Positive regulation of mitotic cell cycle | 4 | 0.016 |
| GO:0045214 | Sarcomere organization | 4 | 0.018 |
| GO:0043486 | Histone exchange | 3 | 0.018 |
| GO:0060968 | Regulation of gene silencing | 3 | 0.018 |
| GO:0006974 | Cellular response to DNA damage stimulus | 10 | 0.019 |
| GO:0060325 | Face morphogenesis | 4 | 0.019 |
| GO:0006278 | RNA-dependent DNA biosynthetic process | 3 | 0.021 |
| GO:0045893 | Positive regulation of transcription, DNA-templated | 18 | 0.021 |
| GO:0007160 | Matrix adhesion | 6 | 0.029 |
| GO:0051726 | Regulation of cell cycle | 7 | 0.032 |
| GO:0080182 | Histone H3-K4 trimethylation | 3 | 0.033 |
| GO:0018105 | Peptidyl-serine phosphorylation | 7 | 0.033 |
| GO:0000183 | Chromatin silencing at rdna | 4 | 0.034 |
| GO:0018117 | Protein adenylylation | 2 | 0.038 |
| GO:0036303 | Lymph vessel morphogenesis | 2 | 0.038 |
| GO:0035574 | Histone H4-K20 demethylation | 2 | 0.038 |
| GO:0043488 | Regulation of mrna stability | 6 | 0.048 |
| Cellular component (CC) | |||
| GO:0005654 | Nucleoplasm | 91 | 4.80E−08 |
| GO:0005634 | Nucleus | 148 | 5.30E−08 |
| GO:0000786 | Nucleosome | 9 | 3.70E−04 |
| GO:0005737 | Cytoplasm | 125 | 8.70E−04 |
| GO:0005720 | Nuclear heterochromatin | 4 | 0.008 |
| GO:0005913 | Cell–cell adherens junction | 14 | 0.008 |
| GO:0019013 | Viral nucleocapsid | 4 | 0.015 |
| GO:0070062 | Extracellular exosome | 66 | 0.035 |
| GO:0002944 | Cyclin K-CDK12 complex | 2 | 0.037 |
| GO:0043234 | Protein complex | 14 | 0.045 |
| GO:0005694 | Chromosome | 6 | 0.046 |
| GO:0000788 | Nuclear nucleosome | 4 | 0.048 |
| Molecular function (MF) | |||
| GO:0044822 | Poly(A) RNA binding | 51 | 2.40E−08 |
| GO:0005515 | Protein binding | 202 | 1.60E−04 |
| GO:0042393 | Histone binding | 10 | 5.80E−04 |
| GO:0016779 | Nucleotidyltransferase activity | 5 | 0.002 |
| GO:0031492 | Nucleosomal DNA binding | 6 | 0.002 |
| GO:0003677 | DNA binding | 50 | 0.002 |
| GO:0003723 | RNA binding | 22 | 0.002 |
| GO:0004674 | Protein serine/threonine kinase activity | 17 | 0.003 |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | 5 | 0.004 |
| GO:0003720 | Telomerase activity | 3 | 0.010 |
| GO:0031625 | Ubiquitin protein ligase binding | 13 | 0.010 |
| GO:0098641 | Cadherin binding involved in cell–cell adhesion | 13 | 0.010 |
| GO:0001968 | Fibronectin binding | 4 | 0.013 |
| GO:0003714 | Transcription corepressor activity | 10 | 0.017 |
| GO:0000166 | Nucleotide binding | 14 | 0.017 |
| GO:0003682 | Chromatin binding | 15 | 0.019 |
| GO:0004672 | Protein kinase activity | 14 | 0.022 |
| GO:0003676 | Nucleic acid binding | 29 | 0.025 |
| GO:0004864 | Protein phosphatase inhibitor activity | 4 | 0.025 |
| GO:0005524 | ATP binding | 40 | 0.031 |
| GO:0070733 | Protein adenylyltransferase activity | 2 | 0.038 |
| GO:0035575 | Histone demethylase activity (H4-K20 specific) | 2 | 0.038 |
| GO:0097493 | Structural molecule activity conferring elasticity | 2 | 0.038 |
| GO:0003779 | Actin binding | 11 | 0.043 |
| GO:0008307 | Structural constituent of muscle | 4 | 0.046 |
| GO:0001046 | Core promoter sequence-specific DNA binding | 4 | 0.049 |