Table 4.
Pathway analysis of upregulated genes in PD.
| Category | Term | Genes | Count | p value |
|---|---|---|---|---|
| KEGG_PATHWAY | hsa04115:p53 signaling pathway | CASP3, TSC2, ATR, MDM4, CCNG1 | 5 | 0.0030 |
| REACTOME_PATHWAY | R-HSA-211227:R-HSA-211227 (Activation of DNA fragmentation factor) | HIST1H1E, CASP3, HIST1H1D | 3 | 0.0085 |
| REACTOME_PATHWAY | R-HSA-1221632:R-HSA-1221632 (Meiotic synapsis) | SYNE2, HIST2H2BE, HIST2H2AC, SUN1, ATR | 5 | 0.0107 |
| REACTOME_PATHWAY | R-HSA-212436:R-HSA-212436 (Generic Transcription Pathway) | ZNF419, ZNF558, ZNF692, ZNF160, ZNF141, ZNF550, ZIK1, ZNF480, ZNF615, ZNF37A | 10 | 0.0160 |
| KEGG_PATHWAY | hsa04151:PI3K-Akt signaling pathway | IL2RA, IL4R, TSC2, VEGFA, PKN2, PIK3CA, ITGA4, BCL2L11 | 8 | 0.0338 |
| KEGG_PATHWAY | hsa05414:Dilated cardiomyopathy | PRKACB, ITGA4, TPM2, TTN | 4 | 0.0392 |
| KEGG_PATHWAY | hsa05206:MicroRNAs in cancer | DNMT3A, CASP3, VEGFA, ZEB2, MDM4, CCNG1, BCL2L11 | 7 | 0.0416 |
| REACTOME_PATHWAY | R-HSA-606279:R-HSA-606279 (Deposition of new CENPA-containing nucleosomes at the centromere) | HIST2H2BE, HIST2H2AC, CENPC, CENPT | 4 | 0.0468 |
| KEGG_PATHWAY | hsa03015:mRNA surveillance pathway | SMG5, SMG1, PABPC1L, NXT2 | 4 | 0.0479 |