Table 1.

Factors involved in regulating lymphatic cell junctions.

Factor	Function	References
Angpt2	Essential for the formation of button-like junction in initial lymphatics	Zheng et al., 2014
	Maintains junctional integrity of collecting vessels
VEGF-C	Secreted from villus macrophages	Suh et al., 2019
	VEGF-C/VEGFR-3 signaling controls button junctions in lacteals
VEGFR-2	VEGF-A/VEGFR-2 signaling regulates zipper junctions in lacteals	Zhang et al., 2018
DLL4	Essential for lacteal regeneration via maintaining button junctions	Bernier-Latmani et al., 2015
	Downstream of VEGFR-2/3
Calcrl	Upstream of Notch/DLL4 signaling in lacteal junctional integrity	Davis et al., 2017
	Controls the transcellular and paracellular transport pathways of chylomicrons	Davis et al., 2019
FOXC1/FOXC2	Required for LEC junction integrity in lymphatic valves, collecting vessels, and dermal lymphatics	Norden et al., 2020 Fatima et al., 2016
S1PR1/LPAR1	Crosstalk between LPAR1 and S1PR1 promotes porous LEC junctions of lymph nodes	Hisano et al., 2019
EphrinB2/EphB4	Maintains LEC junctions via RhoA-dependent cytoskeletal organization	Frye et al., 2020
RhoA/ROCK	Essential for LEC junction formation in lacteals, lymphatic valves and collecting vessels	Zhang et al., 2018 Norden et al., 2020
	Involved in EphrinB2/EphB4- and S1P/S1PR1-dependent junctional/cytoskeletal changes	Frye et al., 2020 Geng et al., 2020