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. 2021 Jan 14;8:622741. doi: 10.3389/fcell.2020.622741

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Copyright © 2021 Videja, Vilskersts, Korzh, Cirule, Sevostjanovs, Dambrova and Makrecka-Kuka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of administration of TMAO at a dose of 120 mg/kg in the drinking water for 14 weeks on heart failure severity-related gene expression (A,B) and BNP protein expression (C) in right ventricular tissue of a rat model of monocrotaline-induced heart failure. The results are presented as the mean ± SEM of 6–8 animals. * Indicates a significant difference from the control group [one-way ANOVA followed by Dunnett's posttest for (A), Kruskall-Wallis test followed by Dunn's multiple comparison test for (B) and (C)], ^# indicates a significant difference from the MCT group (unpaired t-test), p < 0.05.