Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 14;8:622741. doi: 10.3389/fcell.2020.622741

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Videja, Vilskersts, Korzh, Cirule, Sevostjanovs, Dambrova and Makrecka-Kuka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mitochondrial respiration rate measurements (A) and flux control factors (B) in right ventricular cardiac fibers using different energy substrates after administration of TMAO at a dose of 120 mg/kg for 14 weeks in a model of monocrotaline-induced right ventricle heart failure. The results are presented as the mean ± SEM of 6 animals. * Indicates a significant difference from the control group (one-way ANOVA followed by Dunnett's post-test), ^# indicates a significant difference from the MCT group (unpaired t-test), p < 0.05. Flux control factor, the contribution of each substrate/pathway to the respiration rate; PC, palmitoylcarnitine; ADP, adenosine diphosphate; P, pyruvate; S, succinate; Rot, rotenone; AmA, antimycin A; F, fatty acid oxidation-dependent pathway; N, NADH pathway; LEAK, substrate-dependent state; OXPHOS, oxidative phosphorylation-dependent state; ROX, residual oxygen consumption.