Table 1.

Echocardiographic assessment of right ventricle functionality after administration of TMAO at a dose of 120 mg/kg for 14 weeks in a monocrotaline-induced model of right ventricle heart failure.

	Control	TMAO	MCT	TMAO+MCT
Right ventricular pressure, mmHg	21.9 ± 2	22.7 ± 1.3	33.5 ± 5.3*	26.1 ± 1.8
Right ventricular diastolic area, cm2	0.37 ± 0.02	0.33 ± 0.02	0.5 ± 0.07	0.4 ± 0.04
Right ventricular systolic area, cm2	0.2 ± 0.01	0.21 ± 0.02	0.36 ± 0.07*	0.26 ± 0.03
Right ventricular fractional area change, %	46.6 ± 2.6	37 ± 2.8	29.7 ± 4.8*	37 ± 5

The results are presented as the mean ± SEM of 8–9 animals.

^*Indicates a significant difference from the control group (one-way ANOVA followed by Dunnett's post-test), p < 0.05.