Table 3.

Comparative clinical outcome analysis from brachytherapy series.

Authors	n	MFU (months)	Type	Dose (Gy)	5y-LRFS (%)	5y-OS (%)	Necrosis (%)	Stenosis (%)	PP (%)
Mazeron et al.[34]	50	36-96	LDR	60-70	78	63	6	19	74
Delannes et al.[28]	51	65	LDR	50-65	86	72	23	45	75
Rozan et al.[8]	184	139	LDR	63	86	66	21	45	78
Soria et al.[23]	102	111	LDR	61-70	77	63	1	1	72
Chaudhary et al.[27]	23	21	LDR	50	70	66	0	9	70
Kiltie et al.[33]	31	62	LDR	63.5	81	69	8	44	75
De Crevoisier et al.[9]	144	68	LDR	65	80		26	29	72
Cordoba et al.[25]	73	52	LDR	60	88	82	6.8	6.8	69.1
Crook et al.[26]	67	48	PDR/LDR	60	87		12	9	88
Escande et al.[10]	201	128	PDR/LDR	65	82	79	21.4	24.8	77.1
Makarewicz et al.[35]	33	60	PDR/HDR	51	78.8	85	9	-	84.8
Petera et al.[22]	10	20	HDR	54(a)	100		0	0	100
Rouscoff et al.[12]	12	27	HDR	36/39(c)	83	78	9	9	92
Sharma et al.[29]	14	22	HDR	42-45	86		0	0	93
Kellas-Sleczka et al. (11)	76	76	HDR	42.8/48.2(b)	66	77	2.6	1.3	69.5
Pohankova et al.[36]	26	85	HDR	51	83	92	4	4	73
Marban-Orejas et al.[30]	7	90	HDR	38.4/53(d)	86	100	43	43	86
Present study	29	72	HDR	35/38(e)	86	73	10	7	79

Type: modality of radiation therapy; LDR: Low-dose rate brachytherapy; PDR: Pulse-dose rate brachytherapy; HDR: High-dose rate brachytherapy; n: number of patients; LRFS: local relapse free survival; OS: overall survival; MFU: median follow-up in months; PP: Penile preservation

^(a)54 Gy in 18 fractions over 9 days.

^(b)42.8 Gy for adjuvant setting and 48.2 Gy in sole therapy, with a median fractionation dose of 3.2 Gy.

^(c)36 Gy in 9 fractions over 5 days (in the adjuvant setting: 6 Gy day 1 + 2 x 3.75 Gy from day 2 to day 5) or 39 Gy in 9 fractions over 5 days (in sole therapy: 7 Gy day 1 + 2 x 4 Gy from day 2 to day 5).

^(d)Prescribed dose ranged from 38.4 Gy in 6 days (3.2 Gy in 12 fractions) to 53 Gy in 9 days (3.12 Gy in 17 fractions).

^(e)Median total dose of 35 Gy in 9 fractions over 5 days in the adjuvant setting or 38 Gy in 9 fractions over 5 days in sole therapy.