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Downregulation of TRIM11 inhibits HCC cell proliferation in vitro and cell growth in vivo. (A, B) Expression of TRIM11 in Huh1 and Hep3B cells was downregulated by siRNA transfection. (C, D) The MTT assay showed that downregulated TRIM11 greatly inhibited the proliferation of Huh1 and Hep3B cells in comparison with the control cells. (E, F) Both tumor volume and tumor weight were significantly reduced in siTRIM11-Huh1 cell-injected mice, compared to the control group. *p < 0.05.
