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. 2021 Jan 14;10:563486. doi: 10.3389/fonc.2020.563486

Figure 2.

Figure 2

miR-144-5p and miR-451a altered the proliferation, invasion and migration of cholangiocarcinoma cells in vitro. (A, B) Using miR-144-5p and miR-451a mimics or inhibitor to overexpress (A) or downregulate (B) the expression of miR-144-5p and miR-451a. (C, D) Overexpression of miR-144-5p or miR-451a in HCCC-9810 and TFK1 cells suppressed (C) cell proliferation measured by CCK8, (D) cell invasion and migration detected by matrigel-coated transwell and transwell assay. (E, F) Downregulating the expression of miR-144-5p or miR-451a in HuCCT1 and RBE cells promoted (E) cell proliferation, (F) cell invasion and migration as measured as (C, D). All experiments were repeated 3 times. Bars represent mean ± S.D. *p < 0.05. **p < 0.01.