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. 2021 Jan 14;10:563486. doi: 10.3389/fonc.2020.563486

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Copyright © 2021 Fu, Yu, Liang, Fan, Dong, Zhang, Chen, Zhu and Chu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-144-5p and miR-451a changed tumor growth in vivo. (A) Using miR-144-5p and miR-451a mimics or inhibitor to overexpress or downregulate the expression of miRNA-144-5p and miRNA-451a in HCCC-9810 cells. (B) Representative images of xenograft tumors derived from miR-144-5p or miR-451a overexpressed- or knockeddown-HCCC-9810 cells. Mice were sacrificed 27 days after subcutaneous inoculation. (C) Tumor weight of xenografts. (D) Tumor volumes were monitored every 3 days. (E) Representative immunohistochemistry staining images of Ki-67 in the indicated tumor tissues, and quantification of Ki-67 positive cells. Bars represent mean ± S.D. (n = 6), *p < 0.05. **p < 0.01.