Table 1.

Correlations between miR-144-5p or miR-451a expression levels and clinicopathological features in cholangiocarcinoma.

Variables		miR-144-5 pexpression level		P-value	miR-451a expression level		P-value
		Low	High		Low	High
Gender	Male	33	23	0.115	29	27	0.445
	Female	18	24		25	17
Age(y)	<60	28	21	0.419	28	21	0.839
	≥60	23	26		26	23
ALB(U/L)	<28	2	2	0.917	3	1	0.269
	28–35	8	6	0.917	10	4	0.255
	>35	41	39	0.826	41	39	0.121
HBsAg	No	21	33	0.005	24	30	0.025
	Yes	30	14		30	14
HCVAg	No	49	46	1.000	51	44	0.250
	Yes	2	1		3	0
Tumor number	Single	25	30	0.158	24	31	0.014
	Multiple	26	17		30	13
Tumor size	<5cm	15	27	0.008	15	27	0.001
	≥5cm	36	20		39	17
TNM stage	I–III	40	41	0.294	48	33	0.107
	IV	11	6		6	11
Vascular invasion	No	22	30	0.046	22	30	0.008
	Yes	29	17		32	14
LN metastasis	No	32	30	1.000	37	25	0.293
	Yes	19	17		17	19

The chi-square tests were adopted to analyze correlation between miR-144-5p or miR-451a levels and clinicopathological features in cholangiocarcinoma. The mean value of expression level was used as the cutoff. Bold values had statistical significance. intrahepatic cholangiocarcinoma=84, perihilar cholangiocarcinoma=14.