Table 8.

Caryophyllaceae-type cyclopeptides as cytotoxic agents, comparing the properties of amino acid (AA) content in their sequences. Each (+) stands for one AA. AAs with colored names indicate their importance in cytotoxic activity of the cyclopeptides.

Peptide name	Sequence	AA, acidic	AA, basic	AA, polar	AA, nonpolar
Segetalin E	Cyclo(-Gly-Tyr-Val-Pro-Leu-Trp-Pro-)			++	+++++
Yunnanin A	Cyclo(-Gly-Tyr-Gly-Gly-Pro-Phe-Pro)			++++	+++
Yunnanin B	Cyclo(-Gly-Ser-δ-HO Ile-Phe-Phe-Ala)			+++	+++
Yunnanin C	Cyclo(-Gly-Ile-Gly-Phe-Tyr-Ser-Pro)			++++	+++
Yunnanin D	Cyclo(-Gly-Ile-Ser-Phe-Arg-Phe-Pro)		+	++	++++
Dichotomin A	Cyclo(-Gly-Thr-Phe-Leu-Tyr-Val)			+++	+++
Dichotomin B	Cyclo(-Gly-Thr-Phe-Leu-Tyr-Thr)			++++	++
Dichotomin C	Cyclo(-Gly-Thr-Phe-Leu-Tyr-Ala)			+++	+++
Dichotomin E	Cyclo(-Gly-Tyr-Ala-Phe-Ala)			++	+++
Dichotomin H	Cyclo(Ala-Pro-Thr-Phe-Tyr-Pro-Leu-Ile)			++	++++++
Dichotomin I	Cyclo(-Val-Pro-Thr-Phe-Tyr-Pro-Leu-Ile)			++	++++++
Cycloleonuripeptide B	Cyclo(-Gly-Pro-Pro-Pro-Tyr-Pro-Pro-Met(O)-Ile)			+++	++++++
Cycloleonuripeptide C	Cyclo(-Gly-Pro-Pro-Pro-Tyr-Pro-Pro-Met(O)-Ile)			+++	++++++
Cherimolacyclopeptide A	Cyclo(-Pro-Gln-Thr-Gly-Met-Leu-Pro-Ile)			+++	+++++
Cherimolacyclopeptide B	Cyclo(-Pro-Gln-Thr-Gly-OMt-Leu-Pro-Ile)			++++	++++
Dianthin A	cyclo-(Ala-Tyr-Asn-Phe-Gly-Leu)			++	++++
Dianthin C	cyclo-(Gly-Pro-Phe-Tyr-Val-Ile)			++	++++
Dianthin D	cyclo-(Gly-Ser-Leu-Pro-Pro-Ile-Phe)			++	+++++
Dianthin E	cyclo-(Gly-Pro-Ile-Ser-Phe-Val)			++	++++
Dianthin F	cyclo-(Gly-Pro-Phe-Val-Phe)			+	++++
Dianthin H	cyclo-(Gly-Pro-Val-Thr-Ile-Phe)			++	++++
Longicalycinin A	cyclo-(Gly-Phe-Tyr-Pro-Phe).			++	+++
Cyclolinopeptide A	Cyclo(-Pro-Pro-Phe-Phe-Leu-Ile-Ile-Leu-Val)				+++++++++
Cyclolinopeptide B	Cyclo(-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile)				+++++++++
Cyclolinopeptide E	Cyclo(-Pro-Leu-Phe-Ile-OMet-Leu-Val-Phe)			+	+++++++