TABLE 4.
Model parameter estimation for the final pharmacokinetic model of HCQ in cynomolgus macaques.
| Parameter | Description | Mean # | IIV CV% * |
| Ke (1/h) | Elimination rate constant from the central compartment (plasma) | 0.236 | 54.3 |
| Vc/F (L) | Apparent volume of the central compartment (plasma) | 114 | 56.3 |
| Ka (1/h) | Absorption rate constant | 0.592 | 29 |
| Acb50 (mg) | Amount of the plasma compartment where the rate to blood is half-maximal | 7.05 | 120 |
| Kbc (1/h) | Rate constant from the blood compartment to plasma | 0.718 | 52.6 |
| Vb/F (L) | Blood compartment volume of distribution | 2.68 | 125 |
| VL/F (L) | Lung compartment volume of distribution | 5.55 | 86 |
| Klc (1/h) | Rate constant from the lung to central compartment | 0.159 | 94.5 |
| Acl50 (mg) | Amount of central compartment where the rate to lung is half-maximal | 0.498 | 222 |
| K cbmax | Maximum rate constant from the central compartment to blood | 2.48 | 131 |
| Kclmax | Maximum rate constant from the central compartment to lung | 1.92 | 78.9 |
| Kpc (1/h) | Rate constant from the peripheral compartment to central compartment | 0.514 | 88.7 |
| Kcp (1/h) | Rate constant from central compartment to peripheral compartment | 0.600 | 122 |
| SDpl (ng/mL) | Standard deviation of the additive residual error for plasma | 0.100E−04 | Fixed |
| PDpl | Proportional residual error for plasma | 0.286 | |
| SDbl (ng/mL) | Standard deviation of the additive residual error for blood | 0.100E−04 | Fixed |
| PDbl | Proportional residual error for blood | 0.118 | |
| SDlu (ng/g) | Standard deviation of the additive residual error for lung tissue | 0.100E−04 | Fixed |
| PDlu | Proportional residual error for lung tissue | 0.514E−01 |
*
IIV: Interindividual variability; CV: coefficient of variation.
#
Due to limited sample size, the RSD% cannot be estimated.