Fig. 3.

Representative histological images of renal interstitial production of renin in anaemic mice. (a and b) ISH (a) and immunohistochemistry (IHC, b) were performed to detect Ren1 mRNA and renin protein, respectively. (c) ISH of Ren1 mRNA in the kidney sections from control and ISAM mice treated with vehicle or C.E.R.A. (6H and 28D, see Fig. 2c). Dashed circles, arrows, and arrowheads indicate glomeruli, JG cells, and interstitial cells, respectively. Scale bars represent 100 μm.