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. 2021 Jan 25;6(1):100021. doi: 10.1016/j.esmoop.2020.100021

Figure 2.

Figure 2

Building an HCC diagnostic model based on cfDNA 5hmC signatures.

(A) The modeling method of the cfDNA 5hmC diagnostic model for distinguishing HCC patients from non-HCC patients. (B) The level of wd-score in HCC patients and non-HCC patients. (C) Receiver operating characteristic (ROC) curves of the cfDNA 5hmC diagnostic prediction model with DhMPs in the training set and test set. (D) Confusion matrices built from the cfDNA 5hmC diagnostic prediction model for distinguishing HCC patients from non-HCC patients in the training set and test set.

5hmC, 5-hydroxymethylcytosine; AUC, area under curve; cfDNA, cell-free DNA; CI, confidence interval; DhMPs, differentially 5hmC modified regions; HCC, hepatocellular carcinoma; wd-score, weighted diagnostic score.