Table 1.

REMAP-COVID domains and arms. Additional domains can be found at www.remapcap.org

Domain	Arms
Antivirala	Hydroxychloroquine	Usual care
Corticosteroidsa	Low dose hydrocortisone	Moderate dose hydrocortisone	Usual care
Immunoglobulinb	Convalescent plasma	Usual care	Monoclonal antibodies
Therapeutic Anticoagulationb	Full dose anticoagulation (DVT/PE)	Thromboprophylaxis
Vitamin Cb	High dose vitamin C	Usual care
Immune Modulation 2 (IM2)b,c	Eritoranc	Apremilastc	Usual care
Platelet Inhibitiond	P2Y12 inhibitor	Aspirin	Usual care
Statinsd	Simvastatin	Usual care
ACE2 RAS Modulationd	ACE inhibitor	ARBe	Usual care
Mechanical Ventilationd	Protocolized mechanical ventilation	Usual care

DVT/PE deep vein thrombosis/pulmonary embolus, IND Investigational New Drug, IRB Institutional Review Board, ACE angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blocker

^aDomain closed in the USA

^bDomain actively enrolling in the USA, in partnership with the ATTACC and ACTIV4a (therapeutic anticoagulation), and LOVIT (Vitamin C) trials

^cEnrolling as an IND domain under FDA oversight

^dProtocol in development or pending activation

^eA fourth arm of an ARB with a chemokine receptor-2 inhibitor may also be offered