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. Author manuscript; available in PMC: 2021 Jan 28.
Published in final edited form as: Biochem Pharmacol. 2017 Feb 27;132:29–37. doi: 10.1016/j.bcp.2017.02.019

Fig. 2.

Fig. 2.

Effects of ZM323881 on the IC50 values of (A) mitoxantrone and (B) SN-38 in parental HEK293/pcDNA3.1 and transfected BCRP-overexpressing HEK/ABCG2-R482, HEK/ABCG2-R482G and HEK/ABCG2-R482T cells. The percentage dose remaining for (C) mitoxantrone and (D) SN-38 after BCRP inhibition to reach IC50 in parental and BCRP-transfected cells. Dashed lines show the mitoxantrone or SN-38 dose prior to BCRP inhibition (100%). Error bars represent the SD. FTC 5 μM is used as positive control for BCRP inhibition.