Table 2.
Cycle characteristics according to different protocols.
| First GnRH-antagonist stimulation (325 cycles) | Minimal ovarian stimulation | P a | P b | ||
|---|---|---|---|---|---|
| First (374 cycles) | Multiple (733 cycles) | ||||
| Duration of Gn stimulation (days) | 9 (8, 10) | 6 (4, 8) | / | <0.001 | / |
| Total dose of Gn (IU) | 2400 (1800, 2925) | 900 (600.00, 1256.25) | / | <0.001 | / |
| Peak E2 level at trigger day (pmol/L) | 7585 (4213.5, 11666.0) (N=320) |
2707 (1630, 4815) (N=365) |
/ | <0.001 | / |
| P level at trigger day (nmol/L) | 2.64 (1.623, 3.683) (N=68) |
1.36 (1.032, 3.105) (N=96) |
/ | 0.005 | / |
| LH level at trigger day (U/L) | 3.14 (2.205, 5.210) (N=67) | 7.96 (5.318, 13.858) (N=96) | / | <0.001 | / |
| Endometrial thickness at trigger day (mm) | 9 (8.5, 10.4) | 6 (5.0, 8.2) | / | <0.001 | / |
| ICSI/IVF | 100/225 | 104/270 | / | 0.390 | / |
| Number of oocytes retrieved | 7 (4, 10) | 2 (1, 4) | 4 (2, 7) | <0.001 | <0.001 |
| Number of MII oocytes | 5 (3, 8.25) | 2 (1, 3) | 3 (1, 4) | <0.001 | <0.001 |
| Number of fertilized oocytes | 5 (3, 7) | 2 (1, 3) | 3 (1, 5) | <0.001 | <0.001 |
| Number of viable embryos | 2 (1, 4) | 1 (0, 2) | 2 (1,3) | <0.001 | <0.001 |
a
First GnRH-antagonist vs. first minimal ovarian stimulation.
b
bFirst GnRH-antagonist vs. multiple minimal ovarian stimulation.
Gn, gonatrodopin; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; MII, meiosis II.