TABLE 1.

Physiologic parameters of tissues for chloroquine in rat and human. Dashes, Not Available.

Tissue		Volume (V)		Plasma Flow (Q)		Fractional Interstitial Spacea
		Ratb,c	Manc	Ratc	Manc
		ml/kg		ml/h per kilogram		%
Liver		32.3	25.7	2191	628.6	16.1
Kidney		5.25	4.45	1385	484.6	27.3
Lung		2.64	7.60	11,181d	2769	33.6
Spleen		0.973	2.60	679	138.6	20.7
Heart		2.19	4.71	574	110.7	32.0
Brain		4.64	20.1	248	315.7	16.2
Muscle		422.7	400	3512	528.9	11.8
Skin		174.5	37.1	758	160.6	38.2
Eye		0.74d	0.214d	99.6d	0.073d	—
Blood		105.3	79.1	18,641	4615	—
Plasma	Artery	21.1	13.7	11,185d	2769d	—
	Vein	42.1	32.1	11,185d	2769d	—
Remainder		290.9	452.1	1735	401	—
GFR (ml/h per kilogram)e	Rat	315
	Human	111

^aFrom Rodgers et al. (2005).

^bCorrected for residual blood volume (Bernareggi and Rowland, 1991).

^cFrom Brown et al. (1997).

^dFrom Feke et al. (1989), Yu et al. (1991), and Geng et al. (2009).

^eFrom Davies and Morris (1993).