. 2021 Feb;376(2):261–272. doi: 10.1124/jpet.120.000385

TABLE 4.

Summary of assigned and fitted chloroquine pharmacokinetic parameters for human (CV%)

Parameter	Description	Estimated Value
CL_u,int	Hepatic clearance (ml/h per kilogram)	1060 (14.5)
ka_oral	Absorption rate constant (h⁻¹)	0.0245 (13.2)
K_D1	Dissociation constant (µg/ml)	0.0228 (8.5)
R	Adjustment factor for Kp	7.0^a
F	Bioavailability (%)	100^b
fu	Free fraction of drug in plasma (%)	40.0^c

^{^a}

Based on multiplying PBPK Kp_tissue values by the ratio of human-to-rat Vss.

^{^b}

^{^c}