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. 2021 Jan 14;11:604262. doi: 10.3389/fgene.2020.604262

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Copyright © 2021 Wu, Wang, Zhu, Chyr, Zhou, Wu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The distributions of recurrence-free survival (RFS)-related alternative splicing (AS) events. (A) Upset figure shows the number of AS events in exon skip (ES), alternate acceptor site (AA), retained intron, alternate terminator (AT), alternate donor site (AD), alternate promoter (AP), and mutually exclusive exons, respectively, and the distributions of these AS events in different genes. For example, there are 179 RFS-related ES events. Of all the genes with these RFS-related ES events, 159 genes only had ES events, two genes had ES and AD events, another two genes had ES and AT events, one gene had ES and AA events, and the last gene had ES, AA, and AP events simultaneously. (B) Bar chart displaying the favorable (HR, hazard ratio < 1) and unfavorable (HR > 1) events in each AS type. (C) Bubble charts presenting the top AS events in each type ranked by P-values. The AS events written in blue, red, and black are located in breast cancer-related genes, triple-negative breast cancer-related genes, and other genes, respectively. The relationships between these genes and diseases were collected from DisGeNET and some previous studies.