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. 2021 Jan 14;11:604262. doi: 10.3389/fgene.2020.604262

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Copyright © 2021 Wu, Wang, Zhu, Chyr, Zhou, Wu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The selection and analysis of recurrence-free survival (RFS)-related alternative splicing (AS) events. (A) The associations of the seven AS events and one gene with RFS. (B) The seven AS events were selected by Lasso method. This panel shows the changes of partial likelihood deviance with λ values. The seven AS events were selected according to the most regularized model such that error is within one standard error of the minimum. (C) The associations of the seven selected AS events and one gene with overall survival. (D) One example for the correlations between AS events and their host genes. It revealed the possible relationships among the low PSI values of ITGB3_42068_AT, high expression levels of ITGB3, and high risk of triple-negative breast cancer survival.