Table 1. US Burden of Disease, 2008 and 2019.
| Disease category | Burden, DALYs, No. (%) | Change in proportion of total DALYs, % | |
|---|---|---|---|
| 2008 (N = 94 399 784) | 2019 (N = 111 074 472) | ||
| Total | 62 392 713 (66.1) | 75 706 718 (68.2) | 3.1 |
| Cardiovascular | |||
| Total | 10 888 855 (11.6) | 12 281 658 (11.1) | –4.1 |
| Ischemic heart disease | 8 189 345 (8.7) | 8 948 089 (8.1) | –7.1 |
| Other cardiovascular diseases | 1 857 071 (2.0) | 2 257 802 (2.0) | 3.3 |
| Hypertension | 842 439 (0.9) | 1 075 767 (1.0) | 8.5 |
| Other | |||
| Total | 9 728 499 (10.3) | 9 787 097 (8.8) | –14.5 |
| Injuries | 3 042 552 (3.2) | 2 954 759 (2.7) | –17.5 |
| Perinatal disordersa | 1 897 649 (2.0) | 1 589 864 (1.4) | –28.8 |
| Self-harm | 1 779 977 (1.9) | 1 903 093 (1.7) | –9.1 |
| Interpersonal violence | 1 267 997 (1.3) | 1 197 087 (1.1) | –19.8 |
| Oral disorders | 846 546 (0.9) | 198 547 (1.1) | 20.3 |
| Urologic diseases | 362 297 (0.4) | 453 761 (0.4) | 6.4 |
| Psoriasis | 326 408 (0.3) | 353 965 (0.3) | –8.1 |
| Sudden infant death syndrome | 205 073 (0.2) | 136 021 (0.1) | –43.6 |
| Cancer | |||
| Total | 9 594 290 (10.2) | 3 057 849 (10.0) | –2.1 |
| Lung cancer | 3 807 647 (4.0) | 4186491 (3.8) | –6.5 |
| Colon and rectum cancer | 1 459 687 (1.6) | 1760640 (1.6) | 2.5 |
| Breast cancer | 1 292 302 (1.4) | 1 403 392 (1.3) | –7.7 |
| Prostate cancer | 714 001 (0.8) | 926 635 (0.8) | 10.3 |
| Leukemia | 604 098 (0.6) | 668 595 (0.6) | –5.9 |
| Non-Hodgkin lymphoma | 525 735 (0.6) | 607 660 (0.5) | –1.8 |
| Ovarian cancer | 394 723 (0.4) | 426 504 (0.4) | –8.2 |
| Liver cancer | 371 578 (0.4) | 551 263 (0.5) | 26.1 |
| Cervical cancer | 198 102 (0.2) | 247 830 (0.2) | –3.6 |
| Uterine cancer | 175 262 (0.2) | 249 557 (0.2) | 21.0 |
| Hodgkin lymphoma | 51 155 (0.1) | 29 282 (<0.1) | –18.1 |
| Mental health | |||
| Total | 7 586 375 (8.0) | 10 606 093 (9.5) | 18.9 |
| Drug use disorders | 3 291 046 (3.5) | 6 121 628 (5.5) | 58.2 |
| Depressive disorders | 2 620 507 (2.8) | 2 652 532 (2.4) | –14.0 |
| Alcohol use disorders | 1 144 800 (1.2) | 1 275 578 (1.1) | –5.3 |
| Eating disorders | 273 056 (0.3) | 261 295 (0.2) | –18.7 |
| Autism | 256 966 (0.3) | 295 060 (0.3) | –2.4 |
| Neurologic | |||
| Total | 6 643 060 (7.0) | 7 775 109 (7.0) | –0.5 |
| Stroke | 3 279 739 (3.5) | 3 826 274 (3.5) | –0.8 |
| Alzheimer and dementias | 1 652 481 (1.8) | 2 026 882 (1.8) | 4.3 |
| Schizophrenia | 981 296 (1.0) | 993 335 (0.9) | –13.9 |
| Parkinson disease | 369 196 (0.4) | 492 368 (0.4) | 13.4 |
| Multiple sclerosis | 186 529 (0.2) | 211 385 (0.2) | –3.7 |
| Motor neuron disease | 173 819 (0.2) | 224 865 (0.2) | 10.0 |
| Respiratory | |||
| Total | 6 195 089 (6.6) | 7 664 787 (6.9) | 4.2 |
| COPD | 4 097 818 (4.4) | 5 021 538 (4.5) | 4.2 |
| Pneumonia | 1 017 898 (1.1) | 1 228 694 (1.1) | –2.6 |
| Asthma | 1 079 373 (1.1) | 1 414 555 (1.3) | 11.4 |
| GI | |||
| Total | 4 020 808 (4.3) | 5 023 554 (4.5) | 6.2 |
| Chronic kidney disease | 1 726 275 (1.8) | 2 287 706 (2.1) | 12.7 |
| Cirrhosis | 1 532 849 (1.6) | 1 825 800 (1.7) | 1.2 |
| Digestive disorders | 578 159 (0.6) | 694 759 (0.6) | 2.1 |
| Inflammatory bowel disease | 183 525 (0.2) | 215 289 (0.2) | –0.3 |
| Endocrine | |||
| Total (diabetes) | 3 492 035 (3.7) | 4 461 171 (4.0) | 8.5 |
| Infection | |||
| Total | 655 999 (0.8) | 487 949 (0.5) | –32.2 |
| HIV/AIDS | 585 527 (0.6) | 415 326 (0.4) | –39.8 |
| STIs, excluding HIV | 45 413 (0.05) | 47 592 (0.04) | 0.0 |
| Tuberculosis | 25 059 (0.03) | 25 031 (0.02) | –11.0 |
| Sensory | |||
| Total (otitis media) | 47 834 (0.05) | 50 140 (0.04) | –10.9 |
Abbreviations: COPD, chronic obstructive pulmonary disease; DALY, disability-adjusted life-year; GI, gastrointestinal; STI, sexually transmitted infection.
a
Includes neonatal disorders.