Table 6.
Non-motor symptoms scores in patients with late onset depressive disorder (LOD) with abnormal versus normal 123I-ioflupane SPECT ratings
| Clinical assessments | Abnormal (n=7) | Normal (n=22) | P value |
| RBDSQ mean (SD) | 4.4 (3.3) | 4.9 (3.4) | 0.86 |
| RBD1Q n (%) | 3 (42.8) | 7 (31.8) | 0.46 |
| PDSS mean (SD) | 102.7 (20.6) | 93.0 (26.2) | 0.38 |
| UPSIT mean (SD) | 21.7 (4.9) | 33.3 (3.2) | <0.001 |
| MoCA mean (SD) | 22.1 (3.5) | 26.2 (3.1) | 0.01 |
| FAB mean (SD) | 16.2 (1.9)* | 17.4 (0.7)* | 0.02 |
| LARS mean (SD) | −19.0 (11.9) | −23.2 (9.7) | 0.26 |
| PHQ-9 mean (SD) | 9.1 (7.9) | 9.5 (6.4) | 0.78 |
| HADS-D mean (SD) | 9.3 (6.1) | 6.7 (4.5) | 0.44 |
| HADS-A mean (SD) | 8.9 (5.1) | 10.3 (5.5) | 0.60 |
| SCOPA-AUT mean (SD) | 19.3 (11.2) | 13.0 (7.3) | 0.20 |
Independent samples t-test, Mann-Whitney U test and Fisher’s exact test.
*Two abnormal 123I-ioflupane SPECT patients with LOD and one normal 123I-ioflupane SPECT patient with LOD did not complete the Frontal Assessment Battery (FAB).
HADS, Hospital Anxiety and Depression Scale; HADS-A, HADS anxiety subscale; HADS-D, HADS depression subscale; LARS, Lille Apathy Rating Scale; MoCA, Montreal Cognitive Assessment; PDSS, Parkinson’s Disease Sleep Scale; PHQ-9, Patient Health Questionnaire-9; RBD1Q, REM Sleep Behaviour Disorder Single Questionnaire; RBDSQ, The REM sleep Behaviour Disorder Screening Questionnaire; SCOPA-AUT, Scales for Outcomes in Parkinson’s Disease-Autonomic; UPSIT, University of Pennsylvania Smell Identification Test.