TABLE 1.

Comparison of red cell, reticulocyte and differential indices in splenectomized vs. non-splenectomized Gardos and Piezo1-HX cases (mean ± SEM, p: student T test).

	Normal range	Gardos-HX (n = 15)			Piezo1-HX (n = 79)
		Splenectomy			Splenectomy
		Yes	No	p	Yes	No	p
N		7	8		8	71
Hb (g/L)	120–160 (female) 130–180 (male)	918.7	1121.1	<0.05	123.717	124.812	0.24
Reticulocyte (G/L)	20–120	34115	17462	0.07	284135	307100	0.78
MCV	80–100	1074.2	922.7	<0.001	10311	967.1	0.25
rMCV (fL)	92–120	96.85.3	93.63.8	0.27	11410	1117	0.66
mMCHC (g/L)	310–360	34312	35323	0.5	36537	37021	0.84
rMCHC (g/L)	270–330	37213	36417	0.1	30529	33418	0.1
ΔMCV (fL)	–	−5.81.9	3.52.5	<0.001	16.36	19.66	0.05
ΔMCHC (g/L)	–	289	106	<0.001	−65.414	−52.48.6	0.21

In Gardos-HX, ΔMCV was significantly lower and MCV and ΔMCHC were significantly higher in splenectomized subjects, in splenectomized or non-splenectomized cases, the differential indices remained discriminant for Gardos or Piezo1-HX.