Table 3.
Associations between neighbourhood variables and BMI, testing interaction with number of risk alleles at selected loci
| Pinteraction | Homozygous low risk (0 risk alleles) |
Heterozygous (one risk allele) |
Homozygous high risk (two risk alleles) |
|
| rs1558902 (FTO) | ||||
| Fast-food proximity | 0.067 | −0.099 (−0.198 to −0.001) | −0.148 (−0.238 to −0.059) | −0.197 (−0.305 to −0.088) |
| Availability of PA facilities | 0.933 | −0.077 (−0.104 to −0.050) | −0.077 (−0.103 to −0.051) | −0.076 (−0.104 to −0.049) |
| rs6567160 (MC4R) | ||||
| Fast-food proximity | 0.009 | −0.096 (−0.188 to −0.003) | −0.177 (−0.271 to −0.083) | −0.258 (−0.386 to −0.130) |
| Availability of PA facilities | 0.606 | −0.078 (−0.104 to −0.051) | −0.075 (−0.102 to −0.049) | −0.073 (−0.103 to −0.043) |
| rs13021737 (TMEM18) | ||||
| Fast-food proximity | 0.993 | −0.135 (−0.226 to −0.043) | −0.135 (−0.234 to −0.036) | −0.135 (−0.279 to 0.008) |
| Availability of PA facilities | 0.076 | −0.080 (−0.106 to −0.053) | −0.071 (−0.098 to −0.043) | −0.061 (−0.093 to −0.030) |
| rs13078960 (CADM2) | ||||
| Fast-food proximity | 0.114 | −0.159 (−0.252 to −0.066) | −0.108 (−0.205 to −0.010) | −0.056 (−0.192 to 0.081) |
| Availability of PA facilities | 0.419 | −0.076 (−0.102 to −0.049) | −0.079 (−0.106 to −0.053) | −0.083 (−0.114 to −0.053) |
| rs10938397 (GNPDA2) | ||||
| Fast-food proximity | 0.328 | −0.115 (−0.215 to −0.015) | −0.141 (−0.230 to −0.052) | −0.167 (−0.274 to −0.061) |
| Availability of PA facilities | 0.694 | −0.076 (−0.102 to −0.049) | −0.077 (−0.103 to −0.051) | −0.079 (−0.106 to −0.051) |
| rs7141420 (NRXN3) | ||||
| Fast-food proximity | 0.520 | −0.152 (−0.257 to −0.048) | −0.135 (−0.227 to −0.043) | −0.118 (−0.224 to −0.012) |
| Availability of PA facilities | 0.125 | −0.071 (−0.097 to −0.044) | −0.077 (−0.102 to −0.051) | −0.083 (−0.110 to −0.056) |
PA, physical activity; SNP, single-nucleotide polymorphism.