Table 1.

PICO information

Population	Intervention(s)	Comparison	Outcome
Patients with a clinical diagnosis of an anxiety disorder, depression, or both conditions simultaneously, who are receiving treatment for their condition(s) in a way that is in concordance with NICE guidelines.	A diet inclusive of prebiotic foods. A diet inclusive of probiotic foods. A diet inclusive of both prebiotic and probiotic foods.	Patients with a clinical diagnosis of an anxiety disorder, depression, or both conditions, who are receiving treatment that is in concordance with NICE guidelines, but are receiving no specific dietary interventions.	Analysis of quantitative measures that assess the impact of an anxiety disorder, depression, or both conditions simultaneously on an individual.

NICE, National Institute for Health and Care Excellence; PICO, population, intervention, comparison, outcome.