Table 1:

Myristoylated viral proteins. The table was adapted from Maurer-Stroh and Frank Eisenhaber, Trends in Microbiology, 2004.⁶

Protein	Virus	Function	N-terminal sequence	Ref.
Nef	Lentiviruses (HIV, SIV)	Membrane targeting to downregulate immune cell surface molecules	GGKWSKSSI	88
Gag	Retroviruses, Poxviruses (HIV)	Binds plasma membrane to initiate viral particle assembly
❖ P17matrix protein	Lentiviruses (HIV, SIV, FIV)		GARASVLSG	89
❖ P15 matrix protein	Gammaretroviruses (e.g. murine and feline leukemia viruses, rat and avian sarcoma virus, avian spleen necrosis virus, baboon and porcine endogenous retroviruses, reticuloendotheliosis virus), human endogenous retrovirus S71, Poxviridae (Fowl pox)		GQTITTPLS	90
❖ P10 matrix protein	Betaretroviruses (mouse mammary tumor virus, Mason-Pfizer monkey virus, simian retrovirus 2, ovine pulmonary adenocarcinoma virus), wooly monkey sarcoma virus, human endogenous retrovirus K, hamster intracisternal A-particle and python endogenous retrovirus		GVSGSKGQK	91
❖ P19 protein of nucleocapsid inner layer	Deltaretroviruses (human/simian T-cell lymphotropic virus, bovine leukemia virus)		GQIFSRSAS	92
VP4 coat protein	Picornaviridae [rhino-, cardio-, aphtho-, entero- (echo-, coxsackie-, polio-) viruses]	Virion assembly	GAQVSTQKS	93
Large surface antigen	Hepadnaviridae (hepatitis B virus)	Essential for viral infectivity but not assembly	GQNLSTSNP	94
L1R envelope protein	Poxviridae [Chordopoxvirinae (e.g. variola, vaccinia)and Enteropoxvirinae], Asfiviridae, Iridoviridae (lymphocysti-, rana-, iridovirus), Ascoviridae (Ascovirus)	Membrane targeting and virion assembly	GAAASIQTT	95, 96
v-src	Rous sarcoma virus	Membrane binding necessary for oncogenic transformation	GSSKSKPKD	97, 98
A16L late protein	Poxviridae [Chordopoxvirinae (e.g. variola, vaccinia) and Enteropoxvirinae]	Protein associates with viral, not cellular, structures	GAAVTLNRI	99, 100
VP2 coat protein	Polyomaviruses	Viral assembly and infectivity	GAALALLGD	101, 102
G9R	Poxviridae [Chordopoxvirinae (e.g. variola, vaccinia)]	Protein associates with viral, not cellular, structures	GGGVSVELP	99
UL11	Alphaherpesvirinae (simplex-, varicello-, Marek’s disease-like and infectious laryngotracheitis-like viruses)	Association with lipid rafts	GLSFSGARP	103, 104
UL99, U71, BBLF1	Betaherpesvirinae (roseolo-, cytomegalo-, muromegalovirus), Gammaherpesvirinae (e.g. lymphocryptovirus), Alphaherpesvirinae	Association with ERGIC necessary for virion assembly	GAELCKRIC GAKCCKPVS GALWSLCRR	105
Major outer capsid protein μ1	Ortho- and aquareoviruses	Cleavage of μ1 to μ1C	GNASSIVQT	106
E7R	Orthopoxviruses	Soluble protein	GTAATIQTP	99
Polyprotein pp220	Asfivirus	Potential membrane-anchor regulating core assembly	GNRGSSTSS	107, 108
Membrane fusion protein p15	Orthoreovirus	Required for membrane fusion activity	GQRHSIVQP	109, 110