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The Role of TAM Receptors in Immuno-oncology. TAM receptors play a bidirectional role in immuno-oncology, not only promoting tumorigenesis but also activating anti-tumor activity. TAM receptors, Tyro3, Axl, and Mertk receptors; TGF-β, transforming growth factor β; IL, interleukin; M2 macrophages, M2-like phenotype of macrophages; PD-L1, programmed cell death 1 ligand 1; PD-L2, programmed cell death 1 ligand 2; CTLs, cytotoxic T lymphocytes; NK cells, nature kill cells
