Juvenile (P21–25) female mice were subjected to 8 min CA/CPR and were administered saline vehicle, E2, the p38 MAPK inhibitor, SB203580, or E2+ SB203589 at 30 min after resuscitation, and % injured CA1 hippocampal neurons were determined 3 days later. A. Representative H&E images of CA1 injury at 3 days after CA/CPR, scale bars represent 50 μm. B. quantification of % injured neurons. Female and Female + E2 groups are from Fig. 1. * indicated p < 0.05.