Table 3. Impact of Rosuvastatin on Hematological and Biochemical Parameters.
| parameters | normal control | disease control (3 mL/kg distilled water) | piroxicam (10 mg/kg) | rosuvastatin (40 mg/kg) |
|---|---|---|---|---|
| CRP (mg/L) | 3.5 ± 0.86*** | 38.83 ± 1.53 | 10.35 ± 1.51*** | 11.15 ± 0.39*** |
| Hb (g/dL) | 14.18 ± 0.65*** | 8.81 ± 0.97 | 13.41 ± 0.68** | 12.15 ± 0.83*** |
| WBCs (×103/μL) | 8.1 ± 0.63*** | 14.01 ± 1.01 | 9.23 ± 0.54** | 9.49 ± 0.46*** |
| RBCs (×103/μL) | 8.78 ± 0.66*** | 5.83 ± 0.42 | 7.88 ± 0.80** | 7.73 ± 0.62*** |
| platelets (×103/μL) | 840 ± 20.5*** | 1351 ± 18.65 | 891 ± 32.12*** | 901 ± 19.43*** |
| ESR (MM/1st h) | 3.55 ± 0.45*** | 8.65 ± 0.41 | 4.11 ± 0.55*** | 4.38 ± 0.60*** |
| RF (IU/mL) | 6.35 ± 0.59*** | 35.38 ± 0.29 | 9.53 ± 0.91*** | 9.86 ± 0.78*** |
| AST (U/L) | 112.43 ± 5.10*** | 149 ± 3.97 | 119.02 ± 4.52** | 120.01 ± 5.04** |
| ALT (U/L) | 19.87 ± 5.38*** | 50.21 ± 4.21 | 21.43 ± 2.73** | 22.30 ± 2.06*** |
| ALP (U/L) | 157.23 ± 3.85*** | 273.11 ± 4.54 | 165.56 ± 3.14*** | 167.31 ± 5.37*** |
| urea (mg/dL) | 13.53 ± 1.65*** | 31.83 ± 1.97 | 16.74 ± 1.63** | 17.80 ± 2.04*** |
| creatinine (mg/dL) | 0.38 ± 0.11*** | 0.97 ± 0.05 | 0.51 ± 0.03*** | 0.56 ± 0.07** |
a
Data are represented as mean ± SEM, where n = 6, and analyzed by two-way ANOVA followed by the Bonferroni post-test, where ***p < 0.001, **p < 0.01, *p < 0.05, ns = not significant.